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B12 Shots are ideal for individuals experiencing low energy levels, those with certain dietary restrictions (like vegans and vegetarians who may not get enough B12 from their diet), or anyone suffering from conditions that impair nutrient absorption, such as Crohns disease or celiac disease

Several clinical studies have established beyond any possible doubt that the association is statistically much higher than could be expected by chance ( Table 18-5 )

These factors, compounded with reduced oral intake, may have been what led to the intestinal hypoperfusion and colonic ischemia

The SURMOUNT-1 trial (N=2,539), which evaluated tirzepatide 5, 10, and 15 mg, reported cholelithiasis in 1.6% of the tirzepatide arm versus 0.5% with placebo over 72 weeks