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Considering the latter possibility, treatments that were considered failures in previous clinical trials could be reanalyzed for potential efficacy in ALS, taking into account the duration of the disease at the start of therapy. Therefore, using diagnostic criteria that enables earlier identification of the disease and a change in the physicians attitude towards offering an early diagnosis and treatment could result in better ALS patient outcomes.

in the 1970s, [2] in the late 1970s the Bache firm experienced financial difficulties