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Severe abdominal pain, particularly if accompanied by nausea, vomiting, and fever, may indicate pancreatitis, a rare but serious complication that has been reported with incretin-based therapies

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Blockade of the angiotensin II receptor inhibits the negative regulatory feedback of angiotensin II on renin secretion, but the resulting increased plasma renin activity and angiotensin II circulating levels do not overcome the effect of valsartan on blood pressure