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doi: 10.7554/eLife.47327 Summary Keywords high-grade serous ovarian carcinoma (HGSOC), drug resistance mechanisms, molecular markers, personalized treatment, tumor microenvironment Citation Fu R, Hu R, Li W, Lv X, Zhao H and Li F (2025) Unveiling drug resistance pathways in high-grade serous ovarian cancer(HGSOC): recent advances and future perspectives