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FIGURE 4 5.1 Metabolite-mediated intestinal-pulmonary axis crosstalk Gut microbial metabolites, serving as pivotal mediators of host-microbiota interactions, exhibit dynamic composition and functionality regulated by host genetics, dietary patterns, and environmental factors, while reciprocally modulating host homeostasis via the metabolism-immune axis (Schoeler and Caesar, 2019)

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Chrysanthellum americanum aqueous extract significantly reversed this pilocarpines effect in all doses of the treatment groups