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Mitochondrial quality control in health and in Parkinsons disease

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additionally, acute exercise lasting 1 h increased NAD + , NAMPT, and ATP levels in PBMCs while decreasing serum NAM levels, suggesting an increase in NAD + salvage pathway 326

Erastin, a ferroptosis inducer, binds to VDAC2 and VDAC3 on the outer mitochondrial membrane, inducing mitochondrial dysfunction and oxidant release, ultimately triggering ferroptosis in tumor cells