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The most common side effects include: Gastrointestinal Issues: Nausea, vomiting, diarrhea, and constipation are common, especially when starting the medication

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During the peak inflammatory phase, CIA mice developed severe arthritic symptoms and showed broader metabolic alterations in valine/leucine/isoleucine biosynthesis, phenylalanine/tyrosine/tryptophan biosynthesis, and arginine biosynthesis