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Approximately half of those who had discontinued treatment had reinitiated treatment within 3 years after discontinuation, such that the proportion of patients who had ongoing treatment (proportion of patients covered) was approximately 7080% for both drugs during a 15 year period after treatment initiation

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This approach maintains hepatic reserves rather than attempting to replenish them after depletion

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Landau-Kleffner syndrome with mitochondrial respiratory chain-complex I deficiency

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