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the longer-term effect is pressure on local retail pricing and insurance formulary policies

Soon came tirzepatideMounjaro, then Zepbound

The STEP 1 trial showed semaglutide 2.4 mg led to 14.9% weight loss over 68 weeks, while SURMOUNT-1 showed tirzepatide achieved up to 20.9% weight reductionapproaching bariatric surgery outcomes.[6] The SELECT trial (17,604 patients) found semaglutide reduced cardiovascular death, non-fatal heart attack, and non-fatal stroke by 20% and all-cause mortality by 19%, suggesting direct cardioprotective effects beyond weight loss.[4] In STEP-HFpEF, semaglutide produced 13.3% weight loss in heart failure patients and improved symptoms and physical function

The development of these agents underscores the continuous improvement of the pharmacokinetic and pharmacodynamic profiles of these peptide agents [ Table 1 ], expanding their applications beyond T2DM and obesity to encompass cardiovascular disease event reduction [ Table 2 ]