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In December 2023, the European Medicines Agencys Pharmacovigilance Risk Assessment Committee announced an update on its review of GLP-1 RAs and suicidal thoughts and thoughts of self-harm, which began in July 2023
Tirzepatide (Mounjaro) is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist currently licensed for diabetes in the UK
14 Increased oxidative stress in the vasculature, however, is not restricted to the endothelium and has also been demonstrated to occur within the smooth muscle cell layer and the adventitia
The peptide increases survival of enteric neurons, enhances enteric glial cell proliferation, and modulates enteric serotonin release
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