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Recently, it was shown that mitochondria can be cleared upon PINK1-PARKIN mediated mitophagy in the absence of the mATG8-conjugation machinery and independent of lysosomal degradation via a process called autophagic secretion of mitochondria (ASM)

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This is recounted by more than 80% of patients (98) and it has been estimated that two-thirds of ME/CFS cases arise following viral infection (85, 99)

Upon mutation, residue conformation was chosen according to highest probability from the rotamer library (probability is taken from the library that was not affect the structural environment but changed in Phi and Psi angle when Dunbrack library was used)