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However, in severe cases, persistent inflammatory response can lead to sepsis, organ failure, shock, and even death ( Streptococcus pneumoniae , Haemophilus influenzae , Staphylococcus aureus , Escherichia coli, Klebsiella pneumoniae , and Pseudomonas aeruginosa

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So even the topical route, which is the evidence-backed one, should be described as supported by small, sometimes industry-affiliated human cosmetic studies with modest effect sizes, not as proven. The correct posture toward topical GHK-Cu is cautious optimism grounded in real but imperfect human data which is still a materially stronger position than the injectable route can claim