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Deakin, J

doi: 10.1016/j.pathophys.2016.10.001 142 RauchovHVokurkovMPavelkaSBehuliakMTribulovNSoukupT

Key Raw Materials and Suppliers 38 9.2

Hyperinsulinemia and insulin resistance promote tumor growth through various mechanisms: directly by activating the insulin receptor signaling pathway and indirectly by stimulating the insulin-like growth factor (IGF) receptor system, which in turn fosters cellular proliferation, migration, and invasion while inhibiting programmed cell death [11]