Mitochondrial morphology, characterized by fission (division) and fusion (joining), significantly influences cellular susceptibility to ferroptosis
Translational barriers and clinical limitations of CSC-targeted therapies A representative summary of clinical trials and approved CSC-targeting agents, including pathway inhibitors, immune therapies, and metabolic modulators, is provided in Table 1
Potential Side Effects (If Misused) While well-tolerated when dosed properly, side effects can occur if: Dose is too high Used for too long without a break Taken in a fasted or low-blood-sugar state Possible effects include: Mild hypoglycemia (shakiness, dizziness, hunger) Local injection site irritation Temporary water retention Headache or lethargy IGF-1 therapy is generally well tolerated, but dosage, duration, and patient context significantly affect side effect profiles. Cao, J
XOR plays a central role in the production of UA and serves as a rate-limiting enzyme in purine catabolism