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doi: 10.1016/j.molmet.2018.03.011 23 KsterAChaoYBMosiorMFordAGonzalez-DeWhittPAHaleJEet al

Plaintiffs claim that the manufacturers failed to warn that their cows milk-based formulas significantly increase the risk of NEC in premature infants

In this process, 5,10-methylene THF play a critical role in methionine regeneration and methyl donation, meanwhile MTHFR catalyzes the irreversible conversion of 5,10-methylene THF to 5-methyl THF that participate in generation of SAM in methionine cycle and offer methyl group 23