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J Nutr 104:345378

Mechanisms of inhibition of chemical toxicity and carcinogenesis by diallyl sulfide (DAS) and related compounds from garlic

How oxidation and reduction are balanced within the ER lumen is not well-understood, and that understanding is confounded by the observations that neither ablation of both ERO1 isoforms (Zito, Chin, Blais, Harding, & Ron, 2010) nor apparent depletion of total ER glutathione (Tsunoda et al., 2014) appreciably impacts ER protein oxidation capacity or stress sensitivity except for specialized substrates

Besides, there are other supplemental metabolic processes like -oxidation of fatty acids, flavin oxidase pathway and the disproportionation of O 2 radicals for peroxisomal ROS production