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doi:10.1074/jbc.M115.659680 [PDB] 9

Storage temperature range: 36F to 46F (2C to 8C) The precise refrigeration temperature range for semaglutide is 36F to 46F (2C to 8C)

Primary Functions of GLP-1 Blood Sugar Regulation Enhances insulin secretion when glucose levels are high Reduces glucagon release to prevent excess glucose production Improves overall glycemic control Helps maintain stable blood sugar levels throughout the day Appetite and Weight Management Increases feelings of fullness and satiety Reduces hunger signals to the brain Decreases food intake Slows stomach emptying to prolong satisfaction after meals Cardiovascular Health Reduces blood pressure Improves heart function May reduce risk of cardiovascular events Supports healthy blood vessel function Neuroprotective Effects May protect brain cells from damage Potentially reduces inflammation in the nervous system Being studied for neurodegenerative conditions Why People Use GLP-1 Type 2 Diabetes Management: GLP-1 receptor agonists (medications that mimic GLP-1) are highly effective for controlling blood sugar in diabetic patients

This phenocopied the decrease in glucose-derived acetyl-CoA pools following knockdown of the de novo carnitine-synthesis enzyme TMLHE (Extended Data Fig