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As de novo synthesis of ceramide is located in the ER, which is absent in erythrocytes, it is thus assumed that erythrocytic ceramide should directly originate from the hydrolysis of sphingomyelin

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Controversial, but therapeutic doses are unlikely to promote serotonin syndrome

Moran et al., Early mutagenesis studies of the Arabidopsis GS identified a putative glycine-rich loop as important for activity (Wang and Oliver, 1997a,b), which was identified in later structural studies as forming part of the active site (Galant et al., Arabidopsis GS uses a random Ter-reactant mechanism with binding of either ATP or -glutamylcysteine preferred first and addition of glycine last (Jez and Cahoon, Arabidopsis GS and for the eukaryotic homologs (Herrera et al., 2+ to ATP and orienting the -phosphate group in the active site