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Its application to allergic disease specifically relies partly on extrapolation from its known mechanisms (Treg support, Th1/Th2 rebalancing), which are directly relevant to allergy pathophysiology

It has been used for decades to help maintain clear airways and support healthy lung function

Conflict of interest CR has received personal fees from Boehringer Ingelheim, GI Dynamics, Herbalife, Johnson and Johnson, Keyron, Eli Lilly, and Novo Nordisk outside the submitted work

Continuous MT-1 administration beyond 3 weeks causes melanocortin receptor desensitization, where melanocytes downregulate MC1R surface expression in response to sustained agonist binding