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In addition, a decrease was seen in urinary volume, GFR, and filtration fraction in the FA group, followed by an increase in the concentrations of BUN and Cr

Intracellular unstable iron (Fe2+) can produce a large number of ROS through the Fenton reaction, providing sufficient raw materials for lipid peroxidation, and it is also a cofactor of lipid peroxidase (ALOXs and POR), which determines the activity of these enzymes (Fig

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Taken together, these results suggest that 1- pravastatin induces liver mitochondrial redox imbalance that may explain the hepatic side effects reported in a small number of patients, and 2- the co-treatment with safe antioxidants neutralize these side effects