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Zepbound (tirzepatide) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for chronic weight management in adults with obesity or overweight with at least one weight-related comorbidity

Tissue Specificity and Metabolic Effects Importantly, these metabolic effects appear to be tissue-specific to adipose tissue, as studies have not shown similar effects on muscle protein metabolism or bone growth

WHO offers a more moderate evaluation, estimating that approximately 5% of adults globally suffer from depression, with a higher prevalence among women [4]