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In individuals with Angelman Syndrome, the paternal allele of the UBE3A gene is silenced, and the loss of function of the maternal allele leads to the disease ( Prader-Willi Syndrome (PWS) is another neurodevelopmental disorder caused by the loss of paternal gene expression due to a deletion or silencing of the region on chromosome 15 that contains imprinted genes (Nicholls and Knepper, 2001)

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Theyd go back and forth in a fix / find / verify loop, which typically took up to two weeks to complete

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