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Chondrocytes, more specifically, produce cytokines that promote autocrine effects, inducing synthesis of catabolic enzymes and inflammatory mediators, for instance 73 According to reports, inflammatory cytokines interleukin-1 beta (IL-1) and tumor necrosis factor-alpha (TNF-) disrupt cartilage homeostasis and promote degenerative alterations due to the catabolic effects of secreted matrix metalloproteinases (MMPs) which digest cartilage matrix

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K., Kanikarla-Marie, P., Warden, C

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