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The amylin mechanism fills a critical gap in weight loss therapeutics that GLP-1s alone cannot address, explaining the exceptional results seen with dual-pathway combinations

Addition of a small amount of glutathione transferase (GTs) to the reaction mixture of MBB and GSH resulted in a marked increase of fluorescence compared to the mixture without enzyme, demonstrating MBB is a substrate for the enzyme

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This makes perfect sense as erythrocytes take up large amounts of sphingosine and detoxify this sphingolipid by enzymatic conversion to sphingosine-1-phosphate by sphingosine kinase [124]