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Cited studies PMID 40277822 "Benchmark for Setting ACTH Cell Dosage in Clinical Regenerative Medicine for Post-Operative Hypopituitarism" (Journal of Clinical Endocrinology & Metabolism, 2025)

The activated iodine binds to tyrosine residues on thyroglobulin molecules under the action of TPO to produce monoiodotyrosine (MIT) and diiodotyrosine (DIT), which are subsequently coupled to produce T3 or T4 ( Figure 1 )

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S6) described above, whereby the change in local conformational preferences induced by the mutation also contribute to the differences seen in the PRE profiles of the wild-type and Thr1273Glu mutant S tails