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1-4 PIONEER 4: In a double-blind, double-dummy trial with a primary endpoint of mean change in A1C from baseline to Week 26, 711 adult patients with type 2 diabetes receiving metformin alone or metformin with an SGLT-2i were randomized to semaglutide tablets 14 mg (n=285), liraglutide 1.8 mg subcutaneous injection (n=284), or placebo (n=142), all once daily

Semaglutide is an injectable medication originally developed for type 2 diabetes, now FDA-approved for chronic weight management

As a result, you feel full longer and eat less

This slows renal clearance and enzymatic degradation, enabling once-weekly dosing without compromising potency