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Systemic causes Diabetes Obesity Hypothyroidism Pregnancy Menopause Systemic lupus erythematosus Scleroderma Dermatomyositis Renal failure Long-term hemodialysis Acromegaly Multiple myeloma Sarcoidosis Leukaemia Alcoholism Haemophilia PATHOPHYSIOLOGY The most popular ones are mechanical compression, micro-vascular insufficiency, and vibration theories

Iron metabolism Compared with non-malignant cells, the growth of cancer cells is strongly dependent on the micronutrient iron (ferrum in Latin), which is necessary for the ferroptosis process and can be inhibited by various iron-chelating agents

Advancements in science have deepened our understanding of the human body and its functions

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