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In mouse models of AP, NLRP3 deficiency ameliorated pancreatic inflammation and associated complications by reducing neutrophil infiltration (Wu et al., 2020)

It plays a vital role in detoxification, protecting cells from oxidative stress, and supporting liver health

Enzymes that function primarily in the reductive direction utilize the NADP + /NADPH cofactor pair as cofactors as opposed to oxidative enzymes that utilize the NAD + /NADH cofactor pair

Specifically, the ROS scavenger butylated hydroxyanisole delayed TNF-induced necroptosis but had no effect on necroptosis induced by direct RIPK3 oligomerization, suggesting that ROS may facilitate upstream signaling events rather than serve as an obligate execution mechanism 80