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A large number of enzymes that participated in cytosolic glycolysis, gluconeogenesis, the urea cycle, nitrogen metabolism, glycogen metabolism, mitochondrial fatty acid oxidation, the TCA cycle and amino acid catabolism can be regulated by sirtuins

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Crucially, wild-type MZB are known to be prone to activation compared to FoB 7,8,75 , and we found that both Gclc fl/fl Mb1-Cre + FoB and B6 MZB showed a similar increase in mitochondrial mass (Fig