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In order to address the crisis imparted by DPP-IV, sitagliptin (Merck) was the initial lead to embark on the journey towards the upregulation of GLUT-4 expressions in the skeletal muscles of spontaneously hypertensive rats by controlling the postprandial glucose concentration and glycated hemoglobin ( Variously targeted (GLP-1) and off-targeted substrates lead to DPP-IV inhibition, contributing to managing incretin activity and maintaining the basal blood glucose level ( Table 1 ( Table 1 Commercial dipeptidyl peptidase-IV inhibitors

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