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186,187,188,189 In addition, the transcription factor Twist1 upregulates the expression of downstream target genes of TCF4, such as HGF, VEGF, and IGF-1, by forming complexes with TCF4 and -catenin, promoting the proliferation of dermal papilla cells and inducing hair follicle regeneration

The most extensively documented involves upregulation of vascular endothelial growth factor (VEGF) and its receptor VEGFR2, promoting angiogenesis, the formation of new blood vessels, in injured tissue

How BPC-157 (Oral) Works Oral BPC-157 acts primarily through local gastrointestinal mechanisms and, to a debated extent, through systemic absorption from the gut

[DOI] [PMC free article] [PubMed] [Google Scholar] 108.Wyss M., Kaddurah-Daouk R