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In another study, administration of semaglutide prior to LPS decreased levels of the proinflammatory cytokines TNF- and IFN- and reduced circulating levels of the chemoattractant osteopontin (OPN) (9)
These compounds have similar amino acid sequences compared to endogenous GLP-1, with small alterations, a free fatty acid side chain that binds to albumin, explicitly seen in liraglutide and semaglutide, that alter their pharmacokinetic properties (e.g., increased half-life and duration of action) [3]
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