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Gastrointestinal side effects include: Nausea (very common, affecting more than 1 in 10 people): Often most pronounced during dose escalation, typically improving over time Diarrhoea (very common): Can range from mild to severe and may be difficult to distinguish from a Crohn's flare Vomiting (common, affecting up to 1 in 10 people): May contribute to dehydration and electrolyte imbalance Constipation (common): Paradoxically, some patients experience reduced bowel frequency Abdominal pain (common): Can mimic or exacerbate Crohn's-related pain These effects result primarily from delayed gastric emptying and altered gastrointestinal motility