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Factors influencing symptom severity include: Rate of dose titration (slower escalation reduces symptoms) Meal size and composition (large, high-fat meals exacerbate symptoms) Individual variation in GLP-1 receptor sensitivity Concurrent medications affecting gut motility Patients should be counselled that these effects are pharmacologically expected and usually temporary, but persistent or severe symptoms warrant medical review to exclude complications such as pancreatitis, cholelithiasis, or cholecystitis

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Initiation of approved AD treatments is permitted during the trial if deemed medically necessary by investigators

Semaglutide, the active ingredient in Ozempic, may be associated with a lower risk of dementia in people with Type 2 diabetes, according to large observational studies