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doi: 10.3389/fcvm.2023.1129349 Received 21 December 2022 Accepted 28 March 2023 Published 21 April 2023 Volume 10 - 2023 Edited by John Lynn Jefferies, University of Tennessee Health Science Center (UTHSC), United States Reviewed by Zhou Yafeng, Suzhou Dushu Lake Hospital, China Yeliz Demir, Ardahan University, Trkiye Updates Copyright 2023 Zhabyeyev, Sadasivan, Shah, Wang and Oudit

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Yet, from a formulation and manufacturing perspective, these APIs still come with the classic limitation of peptide drugs: they are fragile, easily degraded, and difficult to deliver through the gastrointestinal tract