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Furthermore, certain endogenous active peptides like salicin- can promote high glucose-induced ferroptosis in HK-2 cells by regulating gene expression of antioxidant systems (GPX4 and SLC7A1) and iron metabolism regulatory systems (FTH-1 and TFR-1) (129)

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DSIP has also been shown to potentiate the action of the anticonvulsant drug Valproate in metaphit-provoked generalized epilepsy induced by audiogenic stimulation in adult rats, indicating the potential for using DSIP in combination with antiepileptic drugs for the treatment of seizures [26]