Consistent with our findings in mice, liraglutide treatment caused a 1.6 logfold increase in PCSK1 expression in the -1 subcluster compared with control (Figure 4, A and B, and Supplemental Figure 4A
Geoff Geredien (00:15:02): Absolutely
The effects of peripherally administered des-acyl ghrelin on stomach motility can be inhibited by intracerebrovascular CRH receptor type 2 antagonists, suggesting that CRH receptor type 2 is involved, but there is no direct evidence that des-acyl ghrelin binds this receptor (358) As noted above, the GH-stimulatory actions of ghrelin in vivo seem to require an intact GHRH system, as immunoneutralization of GHRH blocks ghrelin-induced GH secretion (319)
Clin Endocrinol 69(5):737744 Rahman MS, Hossain KS, Das S, Kundu S, Adegoke EO, Rahman MA, Pang MG (2021) Role of insulin in health and disease: an update