glp-1 and perimenopause What GLP-1s Really Do for Women's Bodies Beyond Weight Loss GLP-1 in Your 40s: Perimenopause,

"Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats"

The way we know its the gut bacteria is that if you give people antibiotics to wipe out their friendly flora, you can apparently eat all the steak you want without making any TMAO, but then if you wait a couple weeks until your gut bacteria grows back, youre back to the same problem

The warnings affect the thiazolidinedione class of antidiabetic drugs, which includes rosiglitazone (Avandia), pioglitazone (Actos), rosiglitazone and glimepiride (Avandaryl), rosiglitazone and metformin (Avandamet), and pioglitazone and glimepiride (Duetact)

doi: 10.1038/nrcardio.2011.211