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[44] [45] On 2 April 2026, ESA released first preliminary scientific results from the observations

Titration step values follow the REDEFINE Phase 3 protocol structure as reported by Novo Nordisk and the NEJM publications

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Similar results were apparent in a fast-refeed paradigmtreatment with acyl-GIP significantly reduced food intake in control Gipr AP-GFP animals highly motivated to feed after a 16-h fast, while this effect was lost in Gipr AP-KO animals (Fig