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[18] Access considerations are important for patients to understand: Referral to Tier 3 or 4 specialist weight management services is required for NHS-funded weight management treatment with GLP-1 agonists Local formularies may restrict which GLP-1 agonists are available Supply shortages have affected availability, particularly for higher-dose formulations Private prescriptions may be necessary for those not meeting NHS criteria Ongoing monitoring and specialist input are typically required Patients interested in GLP-1 agonist therapy should discuss their individual circumstances with their GP, who can advise on local referral pathways to specialist services if appropriate
A second family, BPC-157 and TB-500, targets tissue repair rather than the GH axis: BPC-157 is proposed to work through angiogenesis, nitric-oxide signaling, and anti-inflammatory activity, while TB-500 binds actin to promote cell migration, blood-vessel formation, and collagen deposition
0.02 0.03 mMmm, p = 0.003, Fig
