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For someone who already has cardiovascular risk, that makes lycopene-rich, Mediterranean-style eating especially attractive: the same plate that helps arteries may also be nudging prostate risk in the right direction

Pathogenic homozygous or compound heterozygous variants in genes encoding components of this pathwayincluding MC4R, POMC, LEP (leptin), and LEPRcan result in early-onset severe obesity [72]

It is known that excess lipid accumulation in non-adipose tissues is associated with higher concentrations of NEFA and TAG in the circulation, and that this is often accompanied by inflammation, oxidative stress and cellular dysfunction or death ( Reference Mattern and Hardin 53 Reference Perez-Martinez, Perez-Jimenez and Lopez-Miranda 55 )

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