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The incidence, disability rate and mortality rate of cancer have been increasing, and cancer has become one of the main threats to human health ( 2 GLP-1R and its function Glucagon-like peptide-1 (GLP-1), which is mainly secreted by L cells in the colon and distal small intestine, is a newly discovered glucagon-like peptide-1 that can promote insulin secretion and lower the blood sugar peak more effectively than previously reported ( Therefore, GLP-1 has become an important target for glucose homeostasis regulation

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