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Some individuals who achieve significant weight loss and lifestyle changes may retain partial benefits, but this varies considerably

How GLP-1 agonists work Multiple mechanisms: Slow gastric emptying (food stays in stomach longer, you feel full longer) Signal satiety to brain (reduce hunger at neurological level) Improve insulin sensitivity (better blood sugar control) Reduce cravings (especially for hyperpalatable foods) May increase metabolism slightly Why they're so effective: They address the biological drivers of overeating, not just willpower

They represent opposite ends of the aggression spectrum in fat reduction research

Pubertal changes had developed at age 11