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thus, mitochondrial dysfunction may also be involved (Kerckhove et al., 2012) have reported in rat sciatic nerve how bortemozib, as other antitumor drugs, causes significant deficits in complex I and II of ETC, as well as in ATP production, at two time points (pain onset -day 7- and peak pain -day 35-)

Interestingly, chronic alcohol use also impacts the lungs by reducing stores of glutathione

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This review elucidates the impact of lipid imbalance on depression highlighting how dyslipidemia not only makes individuals prone to depression but also exacerbates the progression of depression (including the occurrence of some comorbidities of depression)