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To note, adopting a machine-learning-based classification approach, we found that different classes of progenitor cells express markers of active proliferation in male versus female killifish hematopoietic organs across age groups, which might in principle lead to functional shifts in effector cell abundance and function in either sex

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C., Hoefner, K

Rather, it is more probable that the weight loss yielded by treatment with these drugs may induce intrinsic physiologic and hormonal changes that induce or exacerbate acne vulgaris in such patients. The study did have its share of limitations