glp 1 between pregnancies Increased Risk of NICU Stays for Babies Born to Mothers Prescribed GLP-1 Medications in the 90 Days Before Pregnancy GLP-1 receptor agonists and preconception

2 Association mechanisms between intestinal dysbiosis, SCFA reduction, and renal fibrosis in DKD 2.1 Gut dysbiosis and SCFA depletion in DKD Intestinal dysbiosis, characterized by reduced SCFA-producing bacteria and decreased microbial diversity, emerges as a hallmark feature of DKD pathogenesis, directly contributing to renal fibrosis through diminished SCFA production and subsequent activation of inflammatory pathways

Importantly, we demonstrated previously that exendin 939, generally considered a GLP-1R antagonist, enhances compound 2 efficacy (or vice versa ) at the GLP-1R

tirzepatide adds GIP (dual agonist) and retatrutide adds glucagon (triple agonist), with generally larger weight effects in trials but different tolerability profiles

Most patients notice reduced appetite within the first one to two weeks