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Lampropoulos C, Alexandrides T, Tsochatzis S, Kehagias D, Kehagias I

However, regardless of this is the isoform with the highest sensitivity to citrate in normal tissues 178 , phosphofructokinase-1 in tumors exhibits reduced sensitivity to citrate, accompanied by increased sensitivity to activation by fructose-1,-6-bisphosphate 179,180,181