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The original clinical development, by the Canadian biotech ConjuChem, was discontinued, and there is no validated disease endpoint for either version
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Systemic absorption and hormonal effects Though rare, especially in children using low-potency steroids correctly, it is possible for steroids applied to large surface areas or used frequently to be absorbed into the bloodstream
Thus, Braf thyrV600E , Mieap KO/KO and Braf thyrV600E , Atg5 thyrKO/KO mice developed thyroid cancers earlier than Braf thyrV600E mice
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