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In the ACHIEVE-3 head-to-head trial published in The Lancet in February 2026, orforglipron 36 mg delivered 73.6% greater relative weight loss than oral semaglutide (14 mg) in people with type 2 diabetes 9.2% body weight loss vs

Intranasal (a nasal spray) was the formulation tested in early trials and it did work, but was associated with more blood pressure side effects at effective doses

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