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The pivotal SURPASS clinical trial programme, which evaluated the efficacy and safety of tirzepatide in thousands of patients with type 2 diabetes, did not identify RLS or restless leg symptoms as a recognised adverse effect

Bidram M, Zhao Y, Shebardina NG, Baldin AV, Bazhin AV, Ganjalikhany MR, et al

While lowering blood glucose is essential to preventing damage to the kidneys, nerves, eyes and other organs, it is the underlying insulin resistance more so than the high blood glucose level that is causing the cardiovascular problems

This can promote antigen-presenting cell (APC) presentation and increase the binding affinity of the T cell receptor, leading to the activation of specific T cells